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Phenotype Image Detail
Image
Caption Transverse sections from whole-mount embryos stained for beta-gal activity are shown. The E9.0 Engtm1Mle/Eng+ (End +/-) embryo shows staining associated with the endocardium in the ventricular compartment (v) and tightly delineated in the atrioventricular region (av). The endocardium of the Engtm1Mle/Engtm1Mle (End -/-) embryo is rudimentary, with an abnormally large lumen in the common atrial chamber (A) and the bulbus cordis (B). At E9.5 increased trabeculation is observed in the ventricle of the heterozygous embryo; a few beta-gal stained mesenchymal cells (arrowhead) are seen adjacent to the atrioventricular canal. The heart of the homozygous embryo is much larger than that of the control and is devoid of trabeculae; mesenchymal cells are absent. At E10.5 cushion-tissue mesenchyme (arrowhead) from the heterozygous embryo stains strongly positive for beta-gal; in contrast, the heart of the homozygous embryo shows edema and signs of necrosis. Scale bar, 100um.
Copyright This image is from Bourdeau A, J Clin Invest 1999 Nov;104(10):1343-51 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:58502
Associated
Alleles
Symbol Name
Engtm1Mle endoglin; targeted mutation 1, Michelle Letarte
Associated
Genotypes
Allelic Composition Genetic Background
Engtm1Mle/Engtm1Mle involves: 129P2/OlaHsd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory