Phenotype Image Detail

Image

Caption

Transverse sections from whole-mount embryos stained for beta-gal activity are shown. The E9.0 Eng^tm1Mle/Eng⁺ (End +/-) embryo shows staining associated with the endocardium in the ventricular compartment (v) and tightly delineated in the atrioventricular region (av). The endocardium of the Eng^tm1Mle/Eng^tm1Mle (End -/-) embryo is rudimentary, with an abnormally large lumen in the common atrial chamber (A) and the bulbus cordis (B). At E9.5 increased trabeculation is observed in the ventricle of the heterozygous embryo; a few beta-gal stained mesenchymal cells (arrowhead) are seen adjacent to the atrioventricular canal. The heart of the homozygous embryo is much larger than that of the control and is devoid of trabeculae; mesenchymal cells are absent. At E10.5 cushion-tissue mesenchyme (arrowhead) from the heterozygous embryo stains strongly positive for beta-gal; in contrast, the heart of the homozygous embryo shows edema and signs of necrosis. Scale bar, 100um.

Copyright

This image is from Bourdeau A, J Clin Invest 1999 Nov;104(10):1343-51 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:58502

Associated Alleles

Symbol	Name
Eng^tm1Mle	endoglin; targeted mutation 1, Michelle Letarte

Associated Genotypes

Allelic Composition	Genetic Background
Eng^tm1Mle/Eng^tm1Mle	involves: 129P2/OlaHsd * C57BL/6