Phenotype Image Detail

Image

Caption

Top panel shows eyes of live mice, Crygs^Opj/Crygs⁺ ( (Opj/+, left) and Crygs^Opj/Crygs^Opj mice (Opj/Opj, center and right). For the first 2-3 months of life there is little difference in appearance between heterozygous and homozygous mouse eyes, but in the homozygote, opacity increases in severity with age. The lower panel shows isolated lenses for wild type (+/+), heterozygous and homozygous mice at 5 weeks and homozygous at 8 months. At early stages the mutation causes secondary fiber discontinuity, most notably in the homozygous mouse.

Copyright

This image is from Sinha D, J Biol Chem 2001 Mar 23;276(12):9308-15 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:68109

Associated Alleles

Symbol	Name
Crygs^Opj	crystallin, gamma S; opacity due to poor secondary fiber cell junctions

Associated Genotypes

Allelic Composition	Genetic Background
Crygs^Opj/Crygs^+	involves: 102 * C3H/He * T STOCK
Crygs^Opj/Crygs^Opj	involves: 102 * C3H/He * T STOCK