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Phenotype Image Detail
Caption A and B: Representative Oil-Red-O-stained aortic lesions from 6 month old Apoetm1Unc/Apoetm1Unc (A) and Soat1tm1Far/Soat1tm1Far Apoetm1Unc/Apoetm1Unc (B) mice fed a chow diet. Note the pale appearance of the Soat1tm1Far/Soat1tm1Far Apoetm1Unc/Apoetm1Unc lesions due to a paucity of neutral lipids that stain with Oil-Red-O. C and D: Representative sections of plastic-embedded, osmium tetroxide-stained aortic lesions from Ldlrtm1Her/Ldlrtm1Her (C) and Soat1tm1Far/Soat1tm1Far Ldlrtm1Her/Ldlrtm1Her (D) mice fed an atherogenic diet for 2 months. Neutral lipid droplets (thin arrows) and numerous lucencies from cholesterol crystals (thick arrows) are apparent in the Ldlrtm1Her/Ldlrtm1Her lesion (C). Soat1tm1Far/Soat1tm1Far Ldlrtm1Her/Ldlrtm1Her lesions were devoid of osmium tetroxide staining and had fewer cholesterol cyrstals than Ldlrtm1Her/Ldlrtm1Her lesions.
Copyright This image is from Accad M, J Clin Invest 2000 Mar;105(6):711-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61147
Symbol Name
Apoetm1Unc apolipoprotein E; targeted mutation 1, University of North Carolina
Ldlrtm1Her low density lipoprotein receptor; targeted mutation 1, Joachim Herz
Soat1tm1Far sterol O-acyltransferase 1; targeted mutation 1, Bob Farese
Allelic Composition Genetic Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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