Phenotype Image Detail

Image

Caption

Microscopic observation of wild type (a and b) and Serpinc1^tm1Sai/Serpinc1^tm1Sai (c-f) embryos at 15.5 gd. a and c: Hematoxylin-eosin and (b and d) immunochemical staining with antifibrin(ogen) antibody. e and f: Magnification of the areas indicated in d. e: Myocardium. f: Liver. A mutant embryo at 15.5 gd showed degeneration of the myocardium and liver (c). Fibrin(ogen) deposition was observed in the myocardium and sinusoids of the liver (d, e and f). Size bars, 100um.

Copyright

This image is from Ishiguro K, J Clin Invest 2000 Oct;106(7):873-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:65092

Associated Alleles

Symbol	Name
Serpinc1^tm1Sai	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; targeted mutation 1, Hidehiko Saito

Associated Genotypes

Allelic Composition	Genetic Background
Serpinc1^tm1Sai/Serpinc1^tm1Sai	involves: 129S2/SvPas * C57BL/6J