Phenotype Image Detail

Image

Caption

Histology of age-dependent lipid storage in liver and small intestine and age-dependent white adipose tissue (WAT) disappearance in Lipa^tm1Ggb/Lipa^tm1Ggb mice. Hematoxylin/eosin (H&E) staining of paraffin-embedded sections from liver, small intestine, and skin from the back of an 8-month wild type (+/+) mouse, and a 1.5-month, 5-month, and 8-month Lipa^tm1Ggb/Lipa^tm1Ggb (-/-) mouse, as indicated. Notice that the lipids are mainly stored in hepatocytes in younger mice (1.5 months) and then in nonhepatocytes at the age of 5 and 8 months. The lipid accumulation in lamina propria is more significant at 5 months in the mutant mouse. At 8 months, the villi are swollen and full of lipid. Notice that the subcutaneous white adipose tissue are present in the younger mutant mouse, decrease significantly at 5 months, and completely disappear at 8 months. H&E staining of the enlarged lymph node (A), spleen (B), lung (C), and oil red O (ORO) staining of choroid plexus (D) from a 6-month mutant mouse.

Copyright

This image is from Du H, J Lipid Res 2001 Apr;42(4):489-500 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:68812

Associated Alleles

Symbol	Name
Lipa^tm1Ggb	lysosomal acid lipase A; targeted mutation 1, Gregory A Grabowski

Associated Genotypes

Allelic Composition	Genetic Background
Lipa^tm1Ggb/Lipa^tm1Ggb	involves: 129P2/OlaHsd * CF-1