Phenotype Image Detail

Image

Caption

Electron microscopic analysis of longitudinally sectioned cardiac muscle cells from ventricular myocardium (x17,000). A: Sections from wild type myocardia display the regular array of myofibrils with distinct I-bands and A-bands, in addition to well defined Z-bands and M-lines. Sarcoplasmic reticulum is well developed, and most of the mitochondria have elongated shape. B: A transmission electron micrograph through a transverse section of ventricular myocardium of Myh6^tm1Rbns/Myh6⁺ mouse heart. (x17,000). Although both samples were treated identically, the sarcomere lengths in the heterozygote are greatly reduced, and the M-lines are indistinct. The array of myofibrils is wavy and the myofilaments appear misaligned (arrows). The length of the sarcomeres is greatly reduced. The I-bands are indistinguishable and the A-bands occupy the entire length between Z-bands which themselves are thickened. The mitochondria in the plane of section are rounded and irregularly disturbed. A, A-bands; I, I-bands; M, M-lines; MI, mitochondria; Z, Z-bands; SR, sarcoplasmic reticulum.

Copyright

This image is from Jones WK, J Clin Invest 1996 Oct 15;98(8):1906-17 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:36089

Associated Alleles

Symbol	Name
Myh6^tm1Rbns	myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jeffrey Robbins

Associated Genotypes

Allelic Composition	Genetic Background
Myh6^tm1Rbns/Myh6^+	involves: 129P2/OlaHsd