Phenotype Image Detail

Image

Caption

(A) Light microscopy of the lung at 16 hours of age. Large vessels as well as small capillaries bounded by alveolar epithelium are filled with lipid in Lpl^tm1Bres/Lpl^tm1Bres (-/-) pups while clear in controls (+/+). (B) Electron microscopy of alveolar-capillary junction. Control shows red blood cell in close proximity to capillary endothelium, allowing for proper gas exchange. Note lipid-engorged capillaries in mutant pup, with large lipoproteins surrounding the red blood cell on all sides. A, x300; B, x8,250. AS, alveolar space; Lv, large vessel; Epi, alveolar epithelium (pneumocytes); Cap, capillary; L, lipoproteins; N, nucleus of capillary endothelial cell; RBC, red blood cell.

Copyright

This image is from Weinstock PH, J Clin Invest 1995 Dec;96(6):2555-68 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:30062

Associated Alleles

Symbol	Name
Lpl^tm1Bres	lipoprotein lipase; targeted mutation 1, Jan L Breslow

Associated Genotypes

Allelic Composition	Genetic Background
Lpl^tm1Bres/Lpl^tm1Bres	involves: 129S4/SvJae * C57BL/6J