Phenotype Image Detail

Image

Caption

Morphometry of wild type (+/+) and Eya4^tm1Jse/Eya4^tm1Jse (-/-) middle ear cavity in azithromycin-treated mice. A: The eustachian tube opening within tympanic cavity (OpTC) of Eya4^tm1Jse/Eya4^tm1Jse mice was smaller than that in wild type mice. Scale bars: 200um. B: A 3D reconstruction of portions of the middle ear cavity, eustachian tube, and nasopharynx (NO). The moET, isthmus, cartilaginous segment (cartET), and opening of the eustachian tube within the nasopharynx (OpNP) are indicated on the wild type 3D reconstruction. The location of the OpTC is denoted (white asterisk). Scale bar: 300um.

Copyright

This image is from Depreux FF, J Clin Invest 2008 Feb;118(2):651-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:131873

Associated Alleles

Symbol	Name
Eya4^tm1Jse	EYA transcriptional coactivator and phosphatase 4; targeted mutation 1, Jonathan G Seidman

Associated Genotypes

Allelic Composition	Genetic Background
Eya4^tm1Jse/Eya4^tm1Jse	involves: 129S6/SvEvTac * CBA/J