Phenotype Image Detail

Image

Caption

More than 50% of 10 month old Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae mice (mdx:MyoD-/-) exhibited visible fibrosis in the ventricular region (arrow in A and B). Masson trichrome-stained serial sections through mutant hearts revealed the fibrosis to be confined primarily to epicardial portions of the left ventricle (compare C and D to E) and in regions encompassed by hypertrophied myocytes (arrowhead in B). Magnification: B, x40; C-F, x20.

Copyright

This image is from Megeney LA, Proc Natl Acad Sci U S A 1999 Jan 5;96(1):220-5. Copyright 1999 National Academy of Sciences, U.S.A. J:52248

Associated Alleles

Symbol	Name
Dmd^mdx	dystrophin, muscular dystrophy; X linked muscular dystrophy
Myod1^tm1Jae	myogenic differentiation 1; targeted mutation 1, Rudolf Jaenisch

Associated Genotypes

Allelic Composition	Genetic Background
Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae	involves: 129S4/SvJae * C57BL/10ScSn