Phenotype Image Detail

Image

Caption

A and B: Low-power photomicrographs of wild type (A) and Fstl3^tm1Alsc/Fstl3^tm1Alsc (B) pancreas immunocytochemically stained for insulin. C and D: Hematoxylin and eosin staining of the same wild type (C) and mutant (D) tissues. Black arrowheads show numerous capillaries within the mutant islet. E and F: Immunofluorenscence photographs showing insulin (red) and glucagon (green) localization in islets from wild type (E) and mutant (F) mice. In the mutant islets, the majority of green staining is nonspecific staining of red blood cells within the islet, shown by open arrowheads. Glucagon producing alpha cells in both wild type and mutant islets are shown by solid arrowheads. Magnifications: A and B, x5; C-F, x40. Scale bars, A and B, 200um; C-F, 50um.

Copyright

This image is from Mukherjee A, Proc Natl Acad Sci U S A 2007 Jan 23;104(4):1348-53. Copyright 2007 National Academy of Sciences, U.S.A. J:119526

Associated Alleles

Symbol	Name
Fstl3^tm1Alsc	follistatin-like 3; targeted mutation 1, Alan Schneyer

Associated Genotypes

Allelic Composition	Genetic Background
Fstl3^tm1Alsc/Fstl3^tm1Alsc	involves: 129S4/SvJae * C57BL/6 * FVB/N