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Phenotype Image Detail
Image
Caption A-F: Appearance of control (CT) and Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (Rxralpha beta ep-/-) mice at weeks 2 and 24 as indicated. The white arrowhead in E points to reddening and thickening of a mutant ear at week 2, to be compared with its normal appearance in a CT mouse (D). Black arrows in C and F point to skin lesions seen at week 24 on the back and the ears, and on the face and the neck, respectively. G-L: Hematoxylin and eosin stained sections of ear (G-I) and dorsal skin (J-L) of CT and mutant mice at week 2 and 12. White arrows point to dermal/epidermal junction. Yellow arrows point to blood vessels. hf, hair follicle; u, urtriculi. Scale bar, 50um.
Copyright This image is from Li M, Proc Natl Acad Sci U S A 2005 Oct 11;102(41):14795-800. Copyright 2005 National Academy of Sciences, U.S.A. J:102470
Associated
Alleles
Symbol Name
Rxratm4Ipc retinoid X receptor alpha; targeted mutation 4, Pierre Chambon
Rxrbtm1Pcn retinoid X receptor beta; targeted mutation 1, Pierre Chambon
Tg(KRT14-cre/ERT2)1Ipc transgene insertion 1, I Pierre Chambon
Associated
Genotypes
Allelic Composition Genetic Background
Rxratm4Ipc/Rxratm4Ipc
Rxrbtm1Pcn/Rxrbtm1Pcn
Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory