Phenotype Image Detail

Image

Caption

A: Newborn wild type submandibular gland (SMG). B: Newborn Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0 SMG. C: Newborn Fgf10^tm1Wss/Fgf10^tm1Wss SMG. D: Newborn Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0 SMG. The heterozygous mutants (B & C) have fewer ducts and terminal buds than seen in wild type littermates (A). A much smaller, severely hypoplastic gland is seen in the double heterozygous mutant mice (D) compared to the single heterozygous mutant mice (B & C). Scalebar, 50um.

Copyright

This image is from Jaskoll T, BMC Dev Biol 2005;5():11, an open-access article, licensee BioMed Central Ltd. J:119849

Associated Alleles

Symbol	Name
Fgf10^tm1Wss	fibroblast growth factor 10; targeted mutation 1, W Scott Simonet
Fgfr2^tm2Dsn	fibroblast growth factor receptor 2; targeted mutation 2, Clive Dickson
Tg(Pgk1-cre)1Lni	transgene insertion 1, Peter Lonai

Associated Genotypes

Allelic Composition	Genetic Background
Fgf10^tm1Wss/Fgf10^+ Fgfr2^tm2Dsn/Fgfr2^+ Tg(Pgk1-cre)1Lni/0	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
Fgf10^tm1Wss/Fgf10^+	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
Fgfr2^tm2Dsn/Fgfr2^+ Tg(Pgk1-cre)1Lni/0	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6