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Phenotype Image Detail
Image
Caption A: Newborn wild type submandibular gland (SMG). B: Newborn Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 SMG. C: Newborn Fgf10tm1Wss/Fgf10tm1Wss SMG. D: Newborn Fgf10tm1Wss/Fgf10+ Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 SMG. The heterozygous mutants (B & C) have fewer ducts and terminal buds than seen in wild type littermates (A). A much smaller, severely hypoplastic gland is seen in the double heterozygous mutant mice (D) compared to the single heterozygous mutant mice (B & C). Scalebar, 50um.
Copyright This image is from Jaskoll T, BMC Dev Biol 2005;5():11, an open-access article, licensee BioMed Central Ltd. J:119849
Associated
Alleles
Symbol Name
Fgf10tm1Wss fibroblast growth factor 10; targeted mutation 1, W Scott Simonet
Fgfr2tm2Dsn fibroblast growth factor receptor 2; targeted mutation 2, Clive Dickson
Tg(Pgk1-cre)1Lni transgene insertion 1, Peter Lonai
Associated
Genotypes
Allelic Composition Genetic Background
Fgf10tm1Wss/Fgf10+
Fgfr2tm2Dsn/Fgfr2+
Tg(Pgk1-cre)1Lni/0
involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
Fgf10tm1Wss/Fgf10+ involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
Fgfr2tm2Dsn/Fgfr2+
Tg(Pgk1-cre)1Lni/0
involves: 129 * 129X1/SvJ * BALB/c * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory