Phenotype Image Detail

Image

Caption

A: E13.5 wild type mouse. B: E13.5 Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn mouse. C: E13.5 Fgf10^tm1Ska/Fgf10^tm1Ska mouse. The E13.5 wild type submandibular gland (SMG) (A) has achieved the Late Initial Bud Stage, with several branches being seen in the end-bulb epithelium; a small sublingual gland (SL) bud is seen lateral to the SMG bud. In Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn (B) and Fgf10^tm1Ska/Fgf10^tm1Ska (C) embryos, no SMGs are found; undifferentiated mesenchyme is seen in the site normally occupied by SMB epithelia. PS-palatal shelf. Scalebar, 50um.

Copyright

This image is from Jaskoll T, BMC Dev Biol 2005;5():11, an open-access article, licensee BioMed Central Ltd. J:119849

Associated Alleles

Symbol	Name
Fgf10^tm1Ska	fibroblast growth factor 10; targeted mutation 1, Shigeaki Kato
Fgfr2^tm1.1Dsn	fibroblast growth factor receptor 2; targeted mutation 1.1, Clive Dickson

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn	involves: 129P2/OlaHsd * C57BL/6
Fgf10^tm1Ska/Fgf10^tm1Ska	involves: C57BL/6 * CBA