Phenotype Image Detail

Image

Caption

Electron micrographs of ultrathin sections from the tibialis anterior muscle of a Tfam^tm1Lrsn/Tfam^tm1Lrsn Myl1^tm1(cre)Sjb/Myl1⁺ mouse (A) and a control mouse (B). There is marked accumulation of enlarged mitochondria in skeletal muscle, particularly in the subsarcolemmal region, of the mutant mouse. Scale bar, 2um

Copyright

This image is from Wredenberg A, Proc Natl Acad Sci U S A 2002 Nov 12;99(23):15066-71. Copyright 2002 National Academy of Sciences, U.S.A. J:81561

Associated Alleles

Symbol	Name
Myl1^tm1(cre)Sjb	myosin, light polypeptide 1; targeted mutation 1, Steven J Burden
Tfam^tm1Lrsn	transcription factor A, mitochondrial; targeted mutation 1, Nils-Goran Larsson

Associated Genotypes

Allelic Composition	Genetic Background
Myl1^tm1(cre)Sjb/Myl1^+ Tfam^tm1Lrsn/Tfam^tm1Lrsn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6