Phenotype Image Detail

Image

Caption

In vivo thrombosis model in arterioles after ferric chloride induced injury. An arteriole from wild type or Vwf^tm1Wgr/Vwf^tm1Wgr mouse was injured by ferric cholride superfusion and photographed at four time points after injury. A progression in the quality of platelets interacting with the vessel wall is visible in the wild type arteriole (A-D), leading to complete occlusion and blood stasis in D. Arrowheads in C-D show edge of vessel above which is the forming thrombus. Asterisks indicate the center of a thrombus containing unlabeled and bleached platelets. Almost no platelet interactions are visible in the mutant mouse arteriole (E-H). Scale bar 50um

Copyright

This image is from Denis C, Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9524-9. Copyright 1998 National Academy of Sciences, U.S.A. J:49083

Associated Alleles

Symbol	Name
Vwf^tm1Wgr	Von Willebrand factor; targeted mutation 1, Denisa D Wagner

Associated Genotypes

Allelic Composition	Genetic Background
Vwf^tm1Wgr/Vwf^tm1Wgr	involves: 129S2/SvPas * C57BL/6J
Vwf^tm1Wgr/Vwf^+	involves: 129S2/SvPas * C57BL/6J