Phenotype Image Detail

Image

Caption

Gross and histological analyses of spermatogenic abnormalities. (a) Reduced testis size in Pafah1b3^tm1Cla/Pafah1b3^tm1Cla Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} and restored testis size in Pafah1b3^tm1Cla/Pafah1b3^tm1Cla Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b1^tm1Awb/Pafah1b1⁺ mice. (b) Testis weights of 8 week old wild type and mutant mice (means +/-SEM, n=10). (c-n) Testicular (x200 in c,e,g,i,k and m) and epididymal (x200 in d,f,h,j,l and n) histology of adult (8 week old) wild type ( c & d), Pafah1b3^tm1Cla/Pafah1b3^tm1Cla (e & f), Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} (g & h), Pafah1b3^tm1Cla/Pafah1b3^tm1Cla Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} (i & j), Pafah1b3^tm1Cla/Pafah1b3^tm1Cla Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b1^tm1Awb/Pafah1b1⁺ (k & l) and Pafah1b1^tm1Awb/Pafah1b1⁺ (m & n) mice. Note that the degenerating germ cells (D), multinucleated giant cells (M), and numerous vacuoles (V) are present in tubules of the testes of mice in g,i, k and m. Some tubules are devoid of germ cells (*), leaving only Sertoli cells in seminiferous epithelium in mice in i.

Copyright

This image is from Yan W, Proc Natl Acad Sci U S A 2003 Jun 10;100(12):7189-94. Copyright 2003 National Academy of Sciences, U.S.A. J:83818

Associated Alleles

Symbol	Name
Pafah1b1^tm1Awb	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; targeted mutation 1, Anthony Wynshaw-Boris
Pafah1b2^Gt(Betageo)1Cla	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2; gene trap 1, Gary D Clark
Pafah1b3^tm1Cla	platelet-activating factor acetylhydrolase, isoform 1b, subunit 3; targeted mutation 1, Gary D Clark

Associated Genotypes

Allelic Composition	Genetic Background
Pafah1b2^Gt(Betageo)1Cla/Pafah1b2^Gt(Betageo)1Cla	involves: 129S6/SvEvTac
Pafah1b2^Gt(Betageo)1Cla/Pafah1b2^Gt(Betageo)1Cla Pafah1b3^tm1Cla/Pafah1b3^tm1Cla	involves: 129S6/SvEvTac
Pafah1b1^tm1Awb/Pafah1b1^+ Pafah1b2^Gt(Betageo)1Cla/Pafah1b2^Gt(Betageo)1Cla Pafah1b3^tm1Cla/Pafah1b3^tm1Cla	involves: 129S6/SvEvTac