Phenotype Image Detail

Image

Caption

A: Representative radiographs of the distal femur of wild type and Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd mice revealed comparable radiopacity at 4 months (left). At 12 months (right), cortical thinning (arrow) and radiolucency (asterisk) were apparent in the distal femur of thw wild type but not the mutant mice. B: Representative three dimensional re-constructions and two-dimensional cross-sectional scans demonstrated similar architecture in the distal femur of wild type and mutant mice. In keeping with the results from the Faxitron x-ray, trabecular bone (asterisk) and cortical thickness (arrow) were reduced in the femur of 12 month old wild type compared with all other groups.

Copyright

This image is from Richard S, PLoS Genet 2005 Dec;1(6):e74, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:115775

Associated Alleles

Symbol	Name
Khdrbs1^tm1Rchd	KH domain containing, RNA binding, signal transduction associated 1; targeted mutation 1, Stephane Richard

Associated Genotypes

Allelic Composition	Genetic Background
Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6