Phenotype Image Detail

Image

Caption

A: Size of Serpini2^pq/Serpini2^pq mice (center) in relation to wild type (left) and Serpini2^pq/Serpini2⁺ littermates (right) at 8 weeks of age. C-H: Pancreas hematoxylin and eosin histological analyses were performed on 8 week old (C, D, E), 3 week old (F), and 1 week old (G & H) mice. Wild type acinar cells (C) and heterozygous acinar cells (D) at 8 weeks of age were morophologically normal. This is in contrast to homozygous mice at 8 weeks of age (E) and 3 weeks of age (F), where there is a severe loss of exocrine pancreatic acinar cells while duct cells and islet cells (arrows) are normal. Acinar cells are present in pancreas samples from 1 week old homozygous mice (H), but the cells are smaller and show reduced cytosolic volume when compared to wild type littermates (G). Scale bar: 25um

Copyright

This image is from Loftus SK, PLoS Genet 2005 Sep;1(3):e38, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:115744

Associated Alleles

Symbol	Name
Serpini2^pq	serine (or cysteine) peptidase inhibitor, clade I, member 2; pequeno

Associated Genotypes

Allelic Composition	Genetic Background
Serpini2^pq/Serpini2^pq	involves: C57BL/6J