Phenotype Image Detail

Image

Caption

A-C: Six month old wild-type (A), Cp^tm1Hrs/Cp^tm1Hrs (Cp-/-) (B), and Cp^tm1Hrs/Cp^tm1Hrs Heph^sla/Y (Cp-/-Heph-/Y) (C) retinas Perls' stained for iron (blue) and counterstained with hematoxylin and eosin. D: High magnification of Prussian blue Perls' label in 6 month old double mutant retinal pigment epithelium (RPE). E & F: Light photomicrographs of 6 month old double mutant (E) and wild-type (F) retinas after DAB enhancement (brown) of Perls' stain. (G-H) Electron micrographs of RPE from 6 month old double mutant (G) and wild-type (H) eyes. Only the double mutant (G) contains electrondense vesicles (*) sometimes fused with melanosomes.

Copyright

This image is from Hahn P, Proc Natl Acad Sci U S A 2004 Sep 21;101(38):13850-5. Copyright 2004 National Academy of Sciences, U.S.A. J:92620

Associated Alleles

Symbol	Name
Cp^tm1Hrs	ceruloplasmin; targeted mutation 1, Z Leah Harris
Heph^sla	hephaestin; sex-linked anemia

Associated Genotypes

Allelic Composition	Genetic Background
Cp^tm1Hrs/Cp^tm1Hrs Heph^sla/Y	involves: 129X1/SvJ * C57BL/6