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Phenotype Image Detail
Caption A-C: Six month old wild-type (A), Cptm1Hrs/Cptm1Hrs (Cp-/-) (B), and Cptm1Hrs/Cptm1Hrs Hephsla/Y (Cp-/-Heph-/Y) (C) retinas Perls' stained for iron (blue) and counterstained with hematoxylin and eosin. D: High magnification of Prussian blue Perls' label in 6 month old double mutant retinal pigment epithelium (RPE). E & F: Light photomicrographs of 6 month old double mutant (E) and wild-type (F) retinas after DAB enhancement (brown) of Perls' stain. (G-H) Electron micrographs of RPE from 6 month old double mutant (G) and wild-type (H) eyes. Only the double mutant (G) contains electrondense vesicles (*) sometimes fused with melanosomes.
Copyright This image is from Hahn P, Proc Natl Acad Sci U S A 2004 Sep 21;101(38):13850-5. Copyright 2004 National Academy of Sciences, U.S.A. J:92620
Symbol Name
Cptm1Hrs ceruloplasmin; targeted mutation 1, Z Leah Harris
Hephsla hephaestin; sex-linked anemia
Allelic Composition Genetic Background
involves: 129X1/SvJ * C57BL/6

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