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Phenotype Image Detail
Image
Caption (E-T) Whole mount skeletons from newborn mice stained with Alcian blue and Alzarin red. (E-L) Forelimbs, (M-T) hindlimbs. (E & M) Wild type, (F & N) Bmp2tm1Cjt/Bmp2tm1Cjt Tg(Prrx1-cre)1Cjt/0, (G & O) Bmp4tm1Jfm/Bmp4tm1Jfm Tg(Prrx1-cre)1Cjt/0, (H & P) Bmp7tm1Rob/Bmp7tm1Rob, (I & Q) Bmp2tm1Cjt/Bmp2tm1Cjt Bmp4tm1Jfm/Bmp4+ Tg(Prrx1-cre)1Cjt/0, (J & R) Bmp2tm1Cjt/Bmp2+ Bmp4tm1Jfm/Bmp4tm1Jfm Tg(Prrx1-cre)1Cjt/0, (K & S) Bmp2tm1Cjt/Bmp2tm1Cjt Bmp4tm1Jfm/Bmp4tm1Jfm Tg(Prrx1-cre)1Cjt/0, (L & T) Bmp2tm1Cjt/Bmp2tm1Cjt Bmp7tm1Rob/Bmp7tm1Rob Tg(Prrx1-cre)1Cjt/0. Thin red arrow in (F), (I) and (L), defective scapula; thick red arrow in (T), failure of fibula to articulate with knee, and thick black arrow in (L) and (T), missing phalanx in digit III.
Copyright This image is from Bandyopadhyay A, PLoS Genet 2006 Dec 22;2(12):e216, an open-access article distributed under the terms of the Creative Commons Attribution License. J:118257
Associated
Alleles
Symbol Name
Bmp2tm1Cjt bone morphogenetic protein 2; targeted mutation 1, Clifford J Tabin
Bmp4tm1Jfm bone morphogenetic protein 4; targeted mutation 1, James F Martin
Bmp7tm1Rob bone morphogenetic protein 7; targeted mutation 1, Elizabeth J Robertson
Tg(Prrx1-cre)1Cjt transgene insertion 1, Clifford J Tabin
Associated
Genotypes
Allelic Composition Genetic Background
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2tm1Cjt/Bmp2tm1Cjt
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6 * SJL
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp7tm1Rob/Bmp7tm1Rob
Tg(Prrx1-cre)1Cjt/0
involves: 129S/SvEv * C57BL/6 * SJL

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory