Phenotype Image Detail

Image

Caption

(B-E) Five week old control (B & D) and Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0 (C & E) mice stained with Alcian blue to mark cartilage and alzarian red to mark bone. (B) Ankle of the control mouse with strong blue staining lining each joint (arrowheads). (C) Ankle of mutant mouse showing an absence of blue staining in most regions (arrowheads) and a joint fusion between the central (c) and second (2) tarsals (arrow). (D) Control and (E) mutant metatarsal/phalangeal joint which lacks blue staining in articular regions (arrowheads) but retains staining in the growth plate (asterisks). (F) Control forelimb. (G) Mutant forelimb with webbing between the first and second digit (black arrowhead).

Copyright

This image is from Rountree RB, PLoS Biol 2004 Nov;2(11):e355, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:97780

Associated Alleles

Symbol	Name
Bmpr1a^tm2.1Bhr	bone morphogenetic protein receptor, type 1A; targeted mutation 2.1, Richard R Behringer
Bmpr1a^tm2.2Bhr	bone morphogenetic protein receptor, type 1A; targeted mutation 2.2, Richard R Behringer
Tg(Gdf5-cre,-ALPP)1Kng	transgene insertion 1, David M Kingsley

Associated Genotypes

Allelic Composition	Genetic Background
Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0	involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng