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Phenotype Image Detail
Caption Morphology of aortic lesions from proxmila aortic roots. Representative section from the aortic root (at the level of the first coronary) showing lesions in a Apoetm1Unc/Apoetm1Unc mouse at low (x4) (A) and high magnification detail of lower right profile in A (X20). B: Representative section at the aortic root lesion from a Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mouse at low (x4) (C) and high magnification detail of lower right profile in C (x20). D: Lesions in double homozygous mutant mice show more complex features, including a large necrotic core (NC), numerous needle shaped lucencies indicative of cholesterol crystals (C), and fibrous capping (FC) from smooth muscle cells (stained red). Within the lesion core, greenish blue staining represents proteoglycan, and yellow staining represents collagen.
Copyright This image is from Terasawa Y, Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13830-4. Copyright 2000 National Academy of Sciences, U.S.A. J:66419
Symbol Name
Apoetm1Unc apolipoprotein E; targeted mutation 1, University of North Carolina
Ttpatm1Far tocopherol (alpha) transfer protein; targeted mutation 1, Bob Farese
Allelic Composition Genetic Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Apoetm1Unc/Apoetm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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