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Phenotype Image Detail
Image
Caption Morphology of aortic lesions from proxmila aortic roots. Representative section from the aortic root (at the level of the first coronary) showing lesions in a Apoetm1Unc/Apoetm1Unc mouse at low (x4) (A) and high magnification detail of lower right profile in A (X20). B: Representative section at the aortic root lesion from a Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mouse at low (x4) (C) and high magnification detail of lower right profile in C (x20). D: Lesions in double homozygous mutant mice show more complex features, including a large necrotic core (NC), numerous needle shaped lucencies indicative of cholesterol crystals (C), and fibrous capping (FC) from smooth muscle cells (stained red). Within the lesion core, greenish blue staining represents proteoglycan, and yellow staining represents collagen.
Copyright This image is from Terasawa Y, Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13830-4. Copyright 2000 National Academy of Sciences, U.S.A. J:66419
Associated
Alleles
Symbol Name
Apoetm1Unc apolipoprotein E; targeted mutation 1, University of North Carolina
Ttpatm1Far tocopherol (alpha) transfer protein; targeted mutation 1, Bob Farese
Associated
Genotypes
Allelic Composition Genetic Background
Apoetm1Unc/Apoetm1Unc
Ttpatm1Far/Ttpatm1Far
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Apoetm1Unc/Apoetm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory