Phenotype Image Detail

Image

Caption

A: Comparison of whole lungs at postnatal day 1 (P1) showing the development of a single right lobe in the Fgfr2^tm2.3Dsn/Fgfr2⁺ mouse compared with four distinct lobes in the wild type mouse. B-G: Transverse sections through the right lobes stained with hematoxylin-eosin showing partial lobe separation in the mutant right lung (indicated by arrowheads in C), as well as the development of fewer bronchioles lined with ciliated cells and fewer branched alveolar structures (panels D and E). (Panels B and C, scale bars = 4 mm.) In mutants, lung mesenchyme is more compact and often congested with red blood cells (panels F and G). H: Dissected exobital lacrimal glands with their surrounding mesenchyme still attached to the eye and stained with dye carmalum to reveal branching, show a clear lack of gland development in the mutants. I: Comparison of kidneys at P2 reveals severe growth retardation in mutants which does not seem to affect the adrenal glands lying above each kidney. J & K: Sagittal hematoxylin-eosin stained sections through E14.5 embryonic kidneys show the presence of fewer developing nephrons in the cortical region of the mutants. L & M: Hematoxylin-eosin stained transverse section of P2 kidneys, showing fewer and degenerating glomeruli (arrowheads), dilated proximal and distal tubules, and more undifferentiated mesenchyme in mutants.

Copyright

This image is from Hajihosseini MK, Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3855-60. Copyright 2001 National Academy of Sciences, U.S.A. J:72517

Associated Alleles

Symbol	Name
Fgfr2^tm2.3Dsn	fibroblast growth factor receptor 2; targeted mutation 2.3, Clive Dickson

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm2.3Dsn/Fgfr2^+	involves: 129 * C57BL/6 * FVB/N