Phenotype Image Detail

Image

Caption

A: Whole animal contact radiographs of 17.5dpc mice (Faxitron X-Ray, Wheeling, IL). At this age no skeletal elements are detected by soft x-rays in the Runx2^tm1Gss/Runx2^tm1Gss (deltaC/deltaC) compared with wild type and Runx2^tm1Gss/Runx2⁺ mice. B: Radiography of 6-wk mice to visualize phenotype of the heterozygote. Shown is a dorsal view of a wild type mouse with arrow pointing to the clavicle that is missing in the heterozygous mouse. C: Staining of skeletons from 17.5dpc and 18.5dpc embryos with Alizarin red to detect bone and Alcian blue to detect cartilage by standard procedures.

Copyright

This image is from Choi JY, Proc Natl Acad Sci U S A 2001 Jul 17;98(15):8650-5. Copyright 2001 National Academy of Sciences, U.S.A. J:70461

Associated Alleles

Symbol	Name
Runx2^tm1Gss	runt related transcription factor 2; targeted mutation 1, Gary S Stein

Associated Genotypes

Allelic Composition	Genetic Background
Runx2^tm1Gss/Runx2^tm1Gss	involves: 129S7/SvEvBrd * C57BL/6
Runx2^tm1Gss/Runx2^+	involves: 129S7/SvEvBrd * C57BL/6