Phenotype Image Detail

Image

Caption

A & B: Transverse sections of E10.5 Ubr1^tm1Avar/Ubr1^tm1Avar Ubr2^tm1Ytkw/Ubr2^tm1Ytkw (B) and littermate control (A) embryos stained for neurofilaments. C-F: Hematoxylin/eosin stained transverse sections of double homozygous embryos (D & F) and littermate control embryos (+/+ wild type in C; double heterozygous control in E) at ED10.5 (C & D) and ED11.5 (E & F). G & H: Dorsal views of ED11.5 double homozygous (H) and double heterozygous control (G) embryos. Abbreviations: drg: dorsal root ganglion; mt: motor neuron; nt: neural tube; SC: spinal cord; FB: forebrain; HB: hindbrain. Asterisk and arrowheads in H mark the swollen pericardial sac and kinked neural tube, respectively. Scale bars: 200um

Copyright

This image is from An JY, Proc Natl Acad Sci U S A 2006 Apr 18;103(16):6212-7. Copyright 2006 National Academy of Sciences, U.S.A. J:109036

Associated Alleles

Symbol	Name
Ubr1^tm1Avar	ubiquitin protein ligase E3 component n-recognin 1; targeted mutation 1, Alexander Varshavsky
Ubr2^tm1Ytkw	ubiquitin protein ligase E3 component n-recognin 2; targeted mutation 1, Yong Tae Kwon

Associated Genotypes

Allelic Composition	Genetic Background
Ubr1^tm1Avar/Ubr1^tm1Avar Ubr2^tm1Ytkw/Ubr2^tm1Ytkw	involves: 129S1/Sv * C57BL/6