Phenotype Image Detail

Image

Caption

A, B & D-J: Photomicrographs of eyes from wild type (A & E) and Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs (B,D & F-J) mice at ages P10 (A,B,E & F), P14 (G & H) and 2 months (D,I & J). Note the presence of dysplastic changes in the neuroretina (D & I), detachment of the neuroretina from retina pigment epithelium (arrowhead, D), the normal appearance of the mutant mouse lens at P10 (F vs E), mutant mouse lens degeneration (arrows, G) associated with lens capsule (arrow, H) disruption (arrowhead, H) at P14, and mutant mouse lens repair (I & J) associated with posterior lens epithelial cells and regenerated lens capsule (J, arrow). Abbreviations: ONL: outer nuclear layer; INL: inner nuclear layer; GCL: ganglion cell layer Magnifications: A & B: x400; D: x100; E, F, G & I: x40; H & J: x200 Scale bars A: 50um; D & H: 100um E: 250um

Copyright

This image is from McKeller RN, Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3848-53. Copyright 2002 National Academy of Sciences, U.S.A. J:75215

Associated Alleles

Symbol	Name
Cdkn2a^tm1Cjs	cyclin-dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs	involves: 129X1/SvJ * C57BL/6