Phenotype Image Detail

Image

Caption

Skeletal comparison between wild type and Itgb2^tm2Bay/Itgb2^tm2Bay mice. A: Faxitron analysis demonstrates a decreased bone density in the femurs of 5 week old Itgb2^tm2Bay/Itgb2^tm2Bay mice (right) as compared with their wild type counterparts (left). C: Hematoxylin and eosin staining on the metaphysis area of the femurs shows diminished trabecular bone structure in the homozygous mutant mice (right) as compared with wild type mice (left). D: Representative images of the distal femur metaphysis on microcomputed tomography analysis revealed decreased bone volume, trabecular bone number, trabecular bone thickness, and an increased trabecular bone space. E: Alizarin red and Alcian blue double skeletal staining for bone (red) and cartilage (blue) of 1 week old homozygous mutant mice (right) and wild type littermates (left)>

Copyright

This image is from Miura Y, Proc Natl Acad Sci U S A 2005 Sep 27;102(39):14022-7. Copyright 2005 National Academy of Sciences, U.S.A. J:101407

Associated Alleles

Symbol	Name
Itgb2^tm2Bay	integrin beta 2; targeted mutation 2, Baylor College of Medicine

Associated Genotypes

Allelic Composition	Genetic Background
Itgb2^tm2Bay/Itgb2^tm2Bay	B6.129S7-Itgb2^tm2Bay