Phenotype Image Detail

Image

Caption

Representative hematoxylin/eosin stained sections of newborn Ntrk3^tm1Par/Ntrk3^tm1Par mice (P0). The genotype of each mouse was determined by Southern blot analysis. A: Section of a heart demonstrating ventricular septa defects (* and arrowhead). B: Higher magnification of A, with ventricular septa defect (arrowhead) indicated. C: Atrial septa defect (asd) in homozygous mutant mouse heart. D: Higher magnification of C with septum primum (sp) and septum secundum (ss) indicated. E: Section demonstrating thickening of pulmonic valve leaflets (pv). F: Higher magnification of E, with thickening of pulmonic valve leaflet indicated. Abbreviations: rv: right ventricle; lv: left ventricles; pv: pulmonary valve; tv: tricuspid valve; ra: right atrium; la: left atrium. Magnification: A & E: x25; B, C, D & F: x75

Copyright

This image is from Tessarollo L, Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14776-81. Copyright 1997 National Academy of Sciences, U.S.A. J:45083

Associated Alleles

Symbol	Name
Ntrk3^tm1Par	neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Luis F Parada

Associated Genotypes

Allelic Composition	Genetic Background
Ntrk3^tm1Par/Ntrk3^tm1Par	involves: 129S1/Sv * C57BL/6