Phenotype Image Detail

Image

Caption

A: Photomicrographs of coronal sections through proximal tibias of 12 week old wild type (left), Lrp5^tm1Grw/Lrp5⁺ (center), and Lrp5^tm1Grw/Lrp5^tm1Grw (right) mice stained with Toluidine blue. Note the decreased numbers of trabeculae in heterozygous and homozygous mutant mice. The insert numbers represent trabecular BV/TV based on analysis of 6-12 mice of each genotype. B: Fluorescent photomicrographs of bone trabecula from 12 week old wild type, heterozygous and homozygous mutant mice after calcein double labeling. Insert numbers represent mineral MAR based on analysis of nine wild type and six homozygous mutant mice. C: Three-dimensional microCT reconstruction of proximal tibias from 4 week old wild type and homozygous mutant mice, showing reduced trabecular bone volume in the mutant mouse.

Copyright

This image is from Clement-Lacroix P, Proc Natl Acad Sci U S A 2005 Nov 29;102(48):17406-11. Copyright 2005 National Academy of Sciences, U.S.A. J:104382

Associated Alleles

Symbol	Name
Lrp5^tm1Grw	low density lipoprotein receptor-related protein 5; targeted mutation 1, Georges Rawadi

Associated Genotypes

Allelic Composition	Genetic Background
Lrp5^tm1Grw/Lrp5^tm1Grw	involves: 129S1/Sv * 129X1/SvJ