Phenotype Image Detail

Image

Caption

Histological analysis of placentae from 12.5 dpc embryos. A: Placenta from wild type embryo stained with hematoxylin and eosin. Formation of decidua, trophoblast giant cell (arrowheads), spongiotrophoblast, and labyrinthine layers was normal. B: Placenta from Egfr^Wa5/⁺ embryo with reduced Sp and formation of multinucleated trophoblast cells (arrows). C: Placenta from phenotypically normal Egfr^Wa5/Egfr^Wa5 embryo with reduced Sp layer. D: Placenta from severely growth retarded Egfr^Wa5/Egfr^Wa5 embryo. The embryo attached to this placenta was 70% smaller than wild type littermates. Formation of multinucleated trophoblast cells, a highly disorganized Lt layer, and blood pockets were observed. Abbreviations: decidua (De); spongiotrophoblast (Sp); labyrinthine (Lt). Scale bar: 50um

Copyright

This image is from Lee D, Mamm Genome 2004 Jul;15(7):525-36 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:92308

Associated Alleles

Symbol	Name
Egfr^Wa5	epidermal growth factor receptor; waved 5

Associated Genotypes

Allelic Composition	Genetic Background
Egfr^Wa5/Egfr^Wa5	involves: BALB/cAnN * C3H/HeN * C57BL/6J
Egfr^Wa5/Egfr^+	involves: BALB/cAnN * C3H/HeN * C57BL/6J