Phenotype Image Detail

Image

Caption

Hematoxylin/eosin stained testes sections of wild type (A) and Bbs2^tm1Vcs/Bbs2^tm1Vcs (B) mice show that, whereas wild type mice possess numerous flagella in the seminiferous tubules (*), the homozygous mutant mice have no flagella. Some condensed chromatin, indicationg spermatogenesis, is detectable. Transmission electron micrographs through the tracheal cilia of wild type (C) and homozygous mutant (D) mice reveal a normal 9-plus -2 pattern of microtubules. In some cases, vesicles were observed in association with these microtubules in homozygous mice (C arrow). Kidneys from wild type (E) and homozygous mutant mice (F) are shown. Homozygous mice have numerous cysts, some of which involve the glomerulus. Scanning electron microscopic views of renal tubules from wild type (G) and homozygous mutant mice (H) showing primary cilia. Some cells from homozygous mice show abnormally tapered cilia. Magnification: A & B: x100; C & D: xz90,000; E & F: x90; G & H: x2,500

Copyright

This image is from Nishimura DY, Proc Natl Acad Sci U S A 2004 Nov 23;101(47):16588-93. Copyright 2004 National Academy of Sciences, U.S.A. J:94467

Associated Alleles

Symbol	Name
Bbs2^tm1Vcs	Bardet-Biedl syndrome 2; targeted mutation 1, Val C Sheffield

Associated Genotypes

Allelic Composition	Genetic Background
Bbs2^tm1Vcs/Bbs2^tm1Vcs	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)