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Phenotype Image Detail
Image
Caption A: Sections of basal ganglia and adjacent subcortical gray matter from a P10 Sod2tm1Leb/Sod2tm1Leb mouse demonstrates features of early cellular degeneration, including dispersion of cytoplasm, shedding of ribosomes and ballooning of mitochondria (arrow). In the brain regions surrounding the degenerating neurons, occasional swollen neurites are present (*), but most structures are normal and mitochondria are intact. B: Basal ganglia and other CNS regions from control mice sampled showing no similar degenerative neuronal changes. C: Sections (3-mm thick) from heart of P8 homozygous mouse (left) and control (right) mice demonstrate the marked cardiac dilatation observed in approximately 10% of homozygous mutant mice. D: Electron micrographs of myocardium from the dilated heart in C exhibit focal cell death (*) with swollen, damaged mitochondria and abundant lipid-filled vacuoles. E: More extensively damaged regions of the myocardium show degenerative mitochondrial changes characterized by diffuse, electron-dense deposits. Magnification: A & B: x1800; D & E: x2100
Copyright This image is from Lebovitz RM, Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9782-7. Copyright 1996 National Academy of Sciences, U.S.A. J:36148
Associated
Alleles
Symbol Name
Sod2tm1Leb superoxide dismutase 2, mitochondrial; targeted mutation 1, Russell M Lebovitz
Associated
Genotypes
Allelic Composition Genetic Background
Sod2tm1Leb/Sod2tm1Leb B6.129S7-Sod2tm1Leb/J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory