Phenotype Image Detail

Image

Caption

A: Sections of basal ganglia and adjacent subcortical gray matter from a P10 Sod2^tm1Leb/Sod2^tm1Leb mouse demonstrates features of early cellular degeneration, including dispersion of cytoplasm, shedding of ribosomes and ballooning of mitochondria (arrow). In the brain regions surrounding the degenerating neurons, occasional swollen neurites are present (*), but most structures are normal and mitochondria are intact. B: Basal ganglia and other CNS regions from control mice sampled showing no similar degenerative neuronal changes. C: Sections (3-mm thick) from heart of P8 homozygous mouse (left) and control (right) mice demonstrate the marked cardiac dilatation observed in approximately 10% of homozygous mutant mice. D: Electron micrographs of myocardium from the dilated heart in C exhibit focal cell death (*) with swollen, damaged mitochondria and abundant lipid-filled vacuoles. E: More extensively damaged regions of the myocardium show degenerative mitochondrial changes characterized by diffuse, electron-dense deposits. Magnification: A & B: x1800; D & E: x2100

Copyright

This image is from Lebovitz RM, Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9782-7. Copyright 1996 National Academy of Sciences, U.S.A. J:36148

Associated Alleles

Symbol	Name
Sod2^tm1Leb	superoxide dismutase 2, mitochondrial; targeted mutation 1, Russell M Lebovitz

Associated Genotypes

Allelic Composition	Genetic Background
Sod2^tm1Leb/Sod2^tm1Leb	B6.129S7-Sod2^tm1Leb/J