Phenotype Image Detail

Image

Caption

A: Images of 20 month old wild-type (wt/wt, upper), compound heterozygous Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch (TTD/tXPCS, center) and homozygous Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} (TTD/TTD, lower) mice. Note the extreme cachexia in the homozygous mouse and the absence of this phenotype in the wild-type and compound heterozygous mice. B: Radiographs of 20 month old male wild-type (upper), compound heterozygous (center) and homozygous mice (lower). Ageing homozygous mice develop kyphosis and reduction of bone mineral density as shown in the 6-8 segment of the tail vertebrae counted from the pelvis (close-up at right). Note the absence of these features in the compound heterozygous mouse.

Copyright

This image is from Andressoo JO, PLoS Biol 2006 Oct;4(10):e322, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:116054

Associated Alleles

Symbol	Name
Ercc2^tm2(ERCC2)Jhjh	excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, Jan H J Hoeijmakers
Ercc2^tm2Jmch	excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, James R Mitchell

Associated Genotypes

Allelic Composition	Genetic Background
Ercc2^tm2(ERCC2)Jhjh/Ercc2^tm2(ERCC2)Jhjh	involves: 129P2/OlaHsd * C57BL/6
Ercc2^tm2(ERCC2)Jhjh/Ercc2^tm2Jmch	involves: 129P2/OlaHsd * C57BL/6