Phenotype Image Detail

Image

Caption

A& B: Whole mount analyses of Pten^tm1Mak/Pten⁺ and wild-type littermate embryos at E9.5. Severely affected heterozygous embryos are indistinguishable from homozygous embryos ( A Insert), whereas the majority of heterozygous embryos at E9.5 are smaller and unturned (B). Arrows point to the allantois (heterozygous and homozygous) or the umbilical cord with blood vessels (wild-type littermate). C-E: Histological sections of a wild-type and two moribound heterozygous embryos. Both mutants show an enlarged allantois and kinked neuroepithelium. F-K: Transeverse sections through E9.5 embryos. Matched serial sections from wild-type (f-H) and heterozygous (I-K) embryos are shown with the posterior of the embryo at the top of the figure. The neural tube in the heterozygous embryo is open, whereas in wild-type littermates the neural tube in in the process of closing. Abbreviations: allantois (a); heart (h); head fold region (hfr) placenta (pl); neural tube (nt).

Copyright

This image is from Cully M, Proc Natl Acad Sci U S A 2004 Oct 26;101(43):15358-63. Copyright 2004 National Academy of Sciences, U.S.A. J:93530

Associated Alleles

Symbol	Name
Pten^tm1Mak	phosphatase and tensin homolog; targeted mutation 1, Tak W Mak

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm1Mak/Pten^+	B6.129P2-Pten^tm1Mak