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Phenotype Image Detail
Image
Caption Hematoxylin and eosin stained samples from the wild-type (A) and Acancmd/+ mice (B & C), toluidine blue-stained sample from a heterozygote (D), and Alcian blue-stained samples from the wild-type (E) and heterozygotes (F) are shown. Spines of heterozygotes show protrusion of discs [Th3~4 (B) and Th4~5 (C)] or marked herniation at C4~5 (D). Note disappearance of apophyseal cartilage and deformation of vertebral bodies in heterozygotes (B-D) while the spines of the wild type show no remarkable changes (A). Note staining around chondrocytes in the cartilage from heterozygotes (F) while diffuse staining patterns are observed in that from the wild type (E). Magnification: A-C: x10; D: X25; E & F: x125
Copyright This image is from Watanabe H, Proc Natl Acad Sci U S A 1997 Jun 24;94(13):6943-7. Copyright 1997 National Academy of Sciences, U.S.A. J:41498
Associated
Alleles
Symbol Name
Acancmd aggrecan; cartilage matrix deficiency
Associated
Genotypes
Allelic Composition Genetic Background
Acancmd/Acan+ involves: STOCK T tlow Itpr3tf

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory