Phenotype Image Detail

Image

Caption

A: Intimal hyperplasia and disorganized elastic lamellae at 3 months; heomtoxylin and eosin. B & C: Horseradish peroxidase immunostaining using mAbF4/80 specific for mature macrophages performed on 3 month (b) and 5.5 month (c) mice. C: Extensive macrophage infiltration at the adventitial border associated with aneurysmal dilatation. D: Bony metaplasia with hematopoiesis within vessel at the junction of aortic annulus and the ascending aorta at 6 months; Verhoeff-van Gieson. Magnification: x350

Copyright

This image is from Pereira L, Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3819-23. Copyright 1999 National Academy of Sciences, U.S.A. J:54081

Associated Alleles

Symbol	Name
Fbn1^tm2Rmz	fibrillin 1; targeted mutation 2, Francesco Ramirez

Associated Genotypes

Allelic Composition	Genetic Background
Fbn1^tm2Rmz/Fbn1^tm2Rmz	involves: 129S1/Sv * 129X1/SvJ