Phenotype Image Detail

Image

Caption

A: Sagittal paraffin section of a control (either wild-type or heterozygous mice) E10.5 heart stained with hematoxylin and eosin. The myocardial wall of the common centricular chamber shows extensive trabeculation (#) and the endocardial cushions of the atrioventricular canal (*) are well developed. Also, at this stage the truncus arteriosus shows the first signs of the formation of the aorticopulmonary spiral septum. B & C: Sections of hearts from E10.5 Scn5a^tm1Agrc/Scn5a^tm1Agrc embryos. Note the well developed endocardial cushions (*) and truncus arteriosus, but little trabeculation of the ventricular wall (#). D & E: High-magnification views of the cardiomyocytes and endothelial cells from the control (D) and homozygous mouse embryos (E). Arrowheads (in B-E) indicate endothelial cell layer surrounding the trabeculated myocardium and lining the ventricular chamber. Abbreviations: truncus arteriosus (TA) Scalebar: A-C: 100um; D & E: 25um

Copyright

This image is from Papadatos GA, Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6210-5. Copyright 2002 National Academy of Sciences, U.S.A. J:76331

Associated Alleles

Symbol	Name
Scn5a^tm1Agrc	sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Andrew A Grace

Associated Genotypes

Allelic Composition	Genetic Background
Scn5a^tm1Agrc/Scn5a^tm1Agrc	involves: 129 * C57BL/6J