Phenotype Image Detail

Image

Caption

A & B: Hematoxylin and eosin staining of retinal sections of wild-type (A) and Bbs4^tm1Vcs/Bbs4^tm1Vcs (B) mice. The entire photoreceptor layer is absent in the homozygous mouse section. C & D: Labeling of rods with anti-Opsin (green) from a wild-type (C) and homozygous mutant mouse (D). The lack of labeling in the homozygous mutant mouse retinal section confirms the absence of the photoreceptors. E & F: Labeling of rods with anti-Opsin (green) from a 6 week old wild-type (E) and Bbs4^tm1Vcs/Bbs4^tm1Vcs (F) mouse, demonstrating the presence of photoreceptors. The outer nuclear and photoreceptors layers in the homozygous mouse section are approximately one-half the thickness of the wild-type mouse section, indicating significant photoreceptor cell degeneration. Abbreviations: choroids (CH); retinal pigment epithelium (RPE); outer segment (OS); outer nuclear layer (ONL); inner nuclear layer (INL); ganglion cell layer (GCL

Copyright

This image is from Mykytyn K, Proc Natl Acad Sci U S A 2004 Jun 8;101(23):8664-9. Copyright 2004 National Academy of Sciences, U.S.A. J:90812

Associated Alleles

Symbol	Name
Bbs4^tm1Vcs	Bardet-Biedl syndrome 4; targeted mutation 1, Val C Sheffield

Associated Genotypes

Allelic Composition	Genetic Background
Bbs4^tm1Vcs/Bbs4^tm1Vcs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J