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Phenotype Image Detail
Caption Histological survey of tissues in Ptentm1Rps/Pten+ mice. A: Papillary thyroid carcinoma of 18 week old Ptentm1Rps/Pten+ male, hematoxylin/eosin. B: Anti-Ki67 stain of the same thyroid carcinoma. C: A malignant lymphoma of the kidney of a 6 month old Pten heterozygous male, hematoxylin/eosin. D & E: Immunohistochemical analysis of proliferation using anti-Ki67 antibody on prostates of wild-type (d) and heterozygous mutant (e) mice. Arrow points to mitotic figure. F: Prostatic intraepithelial neoplasia found in 17 week heterozygous male. G-I: Mouse uteri. G: Cross-section of the uterus of a 26 week old wild-type mouse. Arrow points to the endometrium. Arrowhead points to the normal gland. H: Cross-section of the uterus of a 31 week old heterozygous mutant mouse. Arrow points to the endometrium. Arrowhead points to the atypical hyperplastic gland. I: Arrowhead points to a region of complex atypical hyperplasia in a 29 week old heterozygous mouse. Magnification: A&F: x400; C,D,& E: x200; G & H: x40; I: x100
Copyright This image is from Podsypanina K, Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1563-8. Copyright 1999 National Academy of Sciences, U.S.A. J:53065
Symbol Name
Ptentm1Rps phosphatase and tensin homolog; targeted mutation 1, Ramon Parsons
Allelic Composition Genetic Background
Ptentm1Rps/Pten+ involves: 129S1/Sv * C57BL/6J

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