Phenotype Image Detail

Image

Caption

A: Hematoxylin/eosin stain of liver of 1 year old Cp^tm1Hrs/Cp^tm1Hrs mouse. B: Perl's stain of liver section of 1 year old wild-type mouse. C: Perl's stain of liver section from homozygous mutant littermate. D: High-power view of C. Arrow indicates iron accumulation in hepatocyte; arrowheads indicate Kupffer cells. E: Perl's stain of 1 year old homozygous mutant mouse spleen. F: High-power view of E. Arrowheads indicate iron within splenic reticuloendothelial cells. Abbreviations: central vein (CV); red pulp (RP) white pulp (WP). Magnification A: x17; B, C & E x8.5; D & F: x100

Copyright

This image is from Harris ZL, Proc Natl Acad Sci U S A 1999 Sep 14;96(19):10812-7. Copyright 1999 National Academy of Sciences, U.S.A. J:57730

Associated Alleles

Symbol	Name
Cp^tm1Hrs	ceruloplasmin; targeted mutation 1, Z Leah Harris

Associated Genotypes

Allelic Composition	Genetic Background
Cp^tm1Hrs/Cp^tm1Hrs	involves: 129X1/SvJ * Black Swiss