About   Help   FAQ
Phenotype Image Detail
Image
Caption A: The epidermis of the control and Slc27a4wrfr/Slc27a4wrfr appears similar, although the dermis appears more cellular in the Slc27a4wrfr/Slc27a4wrfr. At E17.5 the Slc27a4wrfr/Slc27a4wrfr epidermis is thicker with a flattened skin surface. At birth (PO) the Slc27a4wrfr/Slc27a4wrfr epidermis is on average three times thicker then the control (Bars indicate length), as well as having fewer and abnormally arranged keratohyalin granules (brackets). B: Staining for keratin 14 (K14) at E17.5 shows an increased thickness and flattening of the Slc27a4wrfr/Slc27a4wrfr. Keratin 6 (K6) is only express in the Slc27a4wrfr/Slc27a4wrfr. Loricrin (Lor) was not concentrated at the plasma membrane of granular cells in the Slc27a4wrfr/Slc27a4wrfr. C: E17.5 embryos incubated overnight show penetration into the Slc27a4wrfr/Slc27a4wrfr but not the control. D: Oil red O staining shows numerous fat droplets in the squamous layer of the Slc27a4wrfr/Slc27a4wrfr but not the control.
Copyright This image is from Moulson CL, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5274-9. Copyright 2003 National Academy of Sciences, U.S.A. J:83282
Associated
Alleles
Symbol Name
Slc27a4wrfr solute carrier family 27 (fatty acid transporter), member 4; wrinkle free
Associated
Genotypes
Allelic Composition Genetic Background
Slc27a4wrfr/Slc27a4wrfr involves: 129 * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory