Phenotype Image Detail

Image

Caption

(A) As compared with the +/+ wild-type skeleton (lower) the skeleton of the Fgfr3^tm1Wei/Fgfr3^tm1Wei (upper) shows a kinky and elongated tail, as well as bent and longer long bones, especially in the femur. (B) Comparison of the femurs from the +/+ wild-type (left) and the Fgfr3^tm1Wei/Fgfr3^tm1Wei (right). (C-F) Histological analysis of the Fgfr3^tm1Wei/Fgfr3^tm1Wei reveals growth plates (D & F) are longer then the growth plates of the +/+ wild-type (C & E), which is attributable to an increase in proliferating chondrocytes. Abbreviations: hypertrophic zone (HZ); proliferating zone (PZ).

Copyright

This image is from Wang Y, Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4455-60. Copyright 1999 National Academy of Sciences, U.S.A. J:54829

Associated Alleles

Symbol	Name
Fgfr3^tm1Wei	fibroblast growth factor receptor 3; targeted mutation 1, Weizmann Institute of Science

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr3^tm1Wei/Fgfr3^tm1Wei	involves: 129S1/Sv * 129X1/SvJ * MF1