Phenotype Image Detail

Image

Caption

(A) Wild-type embryo at E9.5 (B) Mttp^tm1Sgy/Mttp^tm1Sgy embryo at E9.5 with incomplete closure of the neural tube. (C) E10.5 Mttp^tm1Sgy/Mttp^tm1Sgy embryo that appears necrotic and has incomplete anterior closure of the neural tube. (D) An Mttp^tm1Sgy/Mttp^tm1Sgy embryo with exencephalus at E14.5 (E & F) Hematoxylin and eosin stained yolk sac membranes of wild-type (E) and Mttp^tm1Sgy/Mttp^tm1Sgy mouse at E10.5 showing reduced numbers of blood cells in the blood islands of the Mttp^tm1Sgy/Mttp^tm1Sgy membranes in comparison to the membranes of the wild-type mouse. Vacuolization at the basolateral surfaces of the visceral endoderm (arrow in F).

Copyright

This image is from Raabe M, Proc Natl Acad Sci U S A 1998 Jul 21;95(15):8686-91. Copyright 1998 National Academy of Sciences, U.S.A. J:48934

Associated Alleles

Symbol	Name
Mttp^tm1Sgy	microsomal triglyceride transfer protein; targeted mutation 1, Stephen G Young

Associated Genotypes

Allelic Composition	Genetic Background
Mttp^tm1Sgy/Mttp^tm1Sgy	involves: 129S4/SvJae