Phenotype Image Detail

Image

Caption

Panel A. Development of arthritis in three homozygous females followed by clinical scoring. Panel B. A naive homozygous female with spontaneous arthritis. Panel C. Morphological sections of ankle joints taken from the mouse shown in panel B (** with spontaneous arthritis) compared to a homozygous mouse that does not develop arthritis (healthy **). Sections are stained with hematoxylin and erythrosine (x100). Panel D. The antibody response directed against collagen II and epitopes of collagen II in homozygotes with spontaneous arthritis compared to healthy heterozygotes and homozygotes. The mutant mice with spontaneous arthritis have higher levels of C1, J1 and U1 epitopes.

Copyright

This image is from Hultqvist M, Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12646-51. Copyright 2004 National Academy of Sciences, U.S.A. J:92437

Associated Alleles

Symbol	Name
H2^q	histocompatibility-2, MHC; q variant
Ncf1^m1J	neutrophil cytosolic factor 1; mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
H2^q/? Ncf1^m1J/Ncf1^m1J	B6.Cg-Ncf1^m1J H2^q