AQP4 Vertebrate HGNC

Vertebrate Homology

Source

Alliance of Genome Resources

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	AQP4	HGNC:637 (HGNC) 361 (Entrez Gene) 600308 (OMIM) AQP4 (Alliance of Genome Resources)	Chr18 q11.2	Chr18:26852038-26865803 (-) GRCh38	blindness megalencephalic leukoencephalopathy with subcortical cysts Meniere's disease neuromyelitis optica optic neuritis temporal lobe epilepsy transverse myelitis	P55087 (UniProt \| EBI) NM_001364286 (RefSeq)
mouse	Aqp4	MGI:107387 (MGI) 11829 (Entrez Gene) Gene Tree Aqp4 (Alliance of Genome Resources)	Chr18 8.74 cM	Chr18:15522553-15544039 (-) GRCm39	malaria	ENSMUSG00000024411 (Ensembl Gene Model) ENSMUSP00000159185 (Ensembl) ENSMUST00000238946 (Ensembl)
rat	Aqp4	RGD:2143 (Rat Genome Database) 25293 (Entrez Gene) Aqp4 (Alliance of Genome Resources)	Chr18 p13			P47863 (UniProt \| EBI) NM_001270558 (RefSeq)
zebrafish	aqp4	ZDB-GENE-040724-152 (Zebrafish Model Organism Database) 445293 (Entrez Gene) aqp4 (Alliance of Genome Resources)	Chr20			NP_001003749 (RefSeq) NM_001358313 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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