Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SEC61A1
  • Mouse genes Sec61a1
  • Rat genes Sec61a1
  • Zfish genes sec61a1,sec61a1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sec61a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	SEC61A1	IMP		Human	PMID:28782633
Molecular Function	GO:0005515	protein binding	SEC61A1	IPI	UniProtKB:P27824	Human	PMID:22314232
Molecular Function	GO:0005515	protein binding	SEC61A1	IPI	UniProtKB:P11021	Human	PMID:22796945
Molecular Function	GO:0005515	protein binding	SEC61A1	IPI	UniProtKB:P27824	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	SEC61A1	IPI	UniProtKB:P60059,UniProtKB:P60468,UniProtKB:P69849,UniProtKB:Q15155,UniProtKB:Q5JPE7,UniProtKB:Q969V3,UniProtKB:Q96A33,UniProtKB:Q9BVK8,UniProtKB:Q9UM00	Human	PMID:32820719
Molecular Function	GO:0005515	protein binding	SEC61A1	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	SEC61A1	IPI	UniProtKB:Q16288	Human	PMID:35384245
Molecular Function	GO:0043022	ribosome binding	SEC61A1	IDA		Human	PMID:32820719
Molecular Function	GO:0043022	ribosome binding	Sec61a1	IDA		Mouse	PMID:16705175
Molecular Function	GO:0022857	transmembrane transporter activity	Sec61a1	EXP		Mouse	MGI:MGI:5767071|PMID:14508489
Molecular Function	GO:0022857	transmembrane transporter activity	Sec61a1	EXP		Mouse	MGI:MGI:5767070|PMID:14508490
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SEC61A1	IDA		Human	PMID:27392076
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SEC61A1	IDA		Human	PMID:8616892
Cellular Component	GO:0016020	membrane	SEC61A1	IDA		Human	PMID:22375059
Cellular Component	GO:0005791	rough endoplasmic reticulum	Sec61a1	IDA		Rat	PMID:1423609|RGD:68306
Biological Process	GO:0006613	cotranslational protein targeting to membrane	SEC61A1	IMP		Human	PMID:28782633
Biological Process	GO:0006613	cotranslational protein targeting to membrane	SEC61A1	IDA		Human	PMID:8616892
Biological Process	GO:0007029	endoplasmic reticulum organization	SEC61A1	IMP		Human	PMID:22375059
Biological Process	GO:0021986	habenula development	sec61a1	IMP	ZFIN:ZDB-GENO-120126-1	Zfish	PMID:21945073
Biological Process	GO:0021986	habenula development	sec61a1	IMP	ZFIN:ZDB-MRPHLNO-120117-1	Zfish	PMID:21945073
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	SEC61A1	IMP		Human	PMID:22375059
Biological Process	GO:0031204	post-translational protein targeting to membrane, translocation	SEC61A1	IMP		Human	PMID:29719251
Biological Process	GO:0039019	pronephric nephron development	Sec61a1	IMP		Mouse	MGI:MGI:5816639|PMID:27392076
Biological Process	GO:0039019	pronephric nephron development	sec61a1	IMP		Zfish	PMID:27392076|ZFIN:ZDB-PUB-160709-1
Biological Process	GO:0048793	pronephros development	sec61a1l	IMP	ZFIN:ZDB-MRPHLNO-160907-5	Zfish	PMID:27392076
Biological Process	GO:0048793	pronephros development	sec61a1l	IMP	ZFIN:ZDB-CRISPR-160907-2	Zfish	PMID:27392076
Biological Process	GO:0045048	protein insertion into ER membrane	SEC61A1	IDA		Human	PMID:8616892
Biological Process	GO:0034341	response to type II interferon	Sec61a1	IEP		Rat	PMID:16604358|RGD:2312768
Biological Process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SEC61A1	IMP		Human	PMID:22375059

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern