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Comparative GO Graph (mouse, human, rat)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mmp8

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Apr 26 17:39:58 2021.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmp8
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005509calcium ion bindingMmp8IMPRatPMID:16153442|RGD:2298554
Molecular FunctionGO:0004175endopeptidase activityMMP8IMPHumanPMID:25049354
Molecular FunctionGO:0008237metallopeptidase activityMmp8IDARatPMID:16153442|RGD:2298554
Molecular FunctionGO:0008233peptidase activityMMP8IDAHumanPMID:23845380
Molecular FunctionGO:0004252serine-type endopeptidase activityMMP8IDAHumanPMID:16192646
Molecular FunctionGO:0004252serine-type endopeptidase activityMMP8IDAHumanPMID:2164002
Molecular FunctionGO:0008270zinc ion bindingMmp8IMPRatPMID:16153442|RGD:2298554
Cellular ComponentGO:0062023collagen-containing extracellular matrixMMP8HDAHumanPMID:28344315
Cellular ComponentGO:0005615extracellular spaceMMP8IDAHumanPMID:2164002
Cellular ComponentGO:0005615extracellular spaceMMP8IDAHumanPMID:24784232
Cellular ComponentGO:0005615extracellular spaceMmp8HDAMouseMGI:MGI:5640941|PMID:24006456
Cellular ComponentGO:0005615extracellular spaceMmp8IDARatPMID:16940237|RGD:2298555
Biological ProcessGO:0035987endodermal cell differentiationMMP8IEPHumanPMID:23154389
Biological ProcessGO:0010629negative regulation of gene expressionMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0032693negative regulation of interleukin-10 productionMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0001503ossificationMmp8IEPRatPMID:15052653|RGD:1540385
Biological ProcessGO:0043388positive regulation of DNA bindingMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0010628positive regulation of gene expressionMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0032755positive regulation of interleukin-6 productionMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0046330positive regulation of JNK cascadeMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0043410positive regulation of MAPK cascadeMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:1903980positive regulation of microglial cell activationMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0150078positive regulation of neuroinflammatory responseMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0150078positive regulation of neuroinflammatory responseMmp8IMPRatPMID:25049354|RGD:13792525
Biological ProcessGO:1901224positive regulation of NIK/NF-kappaB signalingMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processMmp8IMPRatPMID:25049354|RGD:13792525
Biological ProcessGO:1903428positive regulation of reactive oxygen species biosynthetic processMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionMmp8IMPMouseMGI:MGI:6201889|PMID:25049354
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionMmp8IMPRatPMID:25049354|RGD:13792525
Biological ProcessGO:0006508proteolysisMMP8IDAHumanPMID:2164002
Biological ProcessGO:0006508proteolysisMmp8IDARatPMID:16153442|RGD:2298554

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory