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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gpnmb

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Apr 26 17:39:58 2021.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpnmb
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0008201heparin bindingGPNMBIDAHumanPMID:19350579
Molecular FunctionGO:0008201heparin bindingGpnmbIDAMouseMGI:MGI:1931898|PMID:11114299
Molecular FunctionGO:0005178integrin bindingGpnmbIDAMouseMGI:MGI:1931898|PMID:11114299
Molecular FunctionGO:0005515protein bindingGPNMBIPIUniProtKB:P20366:PRO_0000033530HumanPMID:12609765
Molecular FunctionGO:0005515protein bindingGPNMBIPIUniProtKB:P00533HumanPMID:26751287
Molecular FunctionGO:0048018receptor ligand activityGPNMBIMPHumanPMID:19350579
Molecular FunctionGO:0045545syndecan bindingGPNMBIPIUniProtKB:P31431HumanPMID:19350579
Cellular ComponentGO:0031410cytoplasmic vesicleGpnmbIDAMouseMGI:MGI:2447547|PMID:12638126
Cellular ComponentGO:0016021integral component of membraneGPNMBIDAHumanPMID:12609765
Cellular ComponentGO:0005887integral component of plasma membraneGpnmbIDAMouseMGI:MGI:1931898|PMID:11114299
Biological ProcessGO:0030282bone mineralizationGpnmbIEPRatPMID:11746512|RGD:632991
Biological ProcessGO:0007155cell adhesionGpnmbIDAMouseMGI:MGI:1931898|PMID:11114299
Biological ProcessGO:0007267cell-cell signalingGPNMBIMPHumanPMID:19350579
Biological ProcessGO:0001818negative regulation of cytokine productionGPNMBIDAHumanPMID:19350579
Biological ProcessGO:2000134negative regulation of G1/S transition of mitotic cell cycleGPNMBIDAHumanPMID:19350579
Biological ProcessGO:1901215negative regulation of neuron deathGPNMBIGIUniProtKB:P00441HumanPMID:22891158
Biological ProcessGO:0050868negative regulation of T cell activationGPNMBIMPHumanPMID:19350579
Biological ProcessGO:0042130negative regulation of T cell proliferationGPNMBIDAHumanPMID:19350579
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionGpnmbIMPMouseMGI:MGI:3836695|PMID:17475886
Biological ProcessGO:0001649osteoblast differentiationGpnmbIEPRatPMID:11746512|RGD:632991
Biological ProcessGO:0030335positive regulation of cell migrationGPNMBIDAHumanPMID:20711474
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGpnmbIDAMouseMGI:MGI:3768878|PMID:18036345
Biological ProcessGO:0031954positive regulation of protein autophosphorylationGPNMBIDAHumanPMID:19350579
Biological ProcessGO:0001934positive regulation of protein phosphorylationGPNMBIDAHumanPMID:22891158
Biological ProcessGO:0001934positive regulation of protein phosphorylationGpnmbIDAMouseMGI:MGI:3768878|PMID:18036345
Biological ProcessGO:0001934positive regulation of protein phosphorylationGpnmbIMPMouseMGI:MGI:5605931|PMID:25010402
Biological ProcessGO:0034103regulation of tissue remodelingGPNMBIDAHumanPMID:25010402
Biological ProcessGO:0034103regulation of tissue remodelingGpnmbIMPMouseMGI:MGI:5605931|PMID:25010402
Biological ProcessGO:0007165signal transductionGPNMBIMPHumanPMID:19350579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory