Comparative GO Graph (mouse, human, rat)

• Source: HomoloGene (Release 68, May 6, 2014)
• Class ID: 68265

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

• This class contains
  • Human genes PDK2
  • Mouse genes Pdk2
  • Rat genes Pdk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD.
• Only experimental annotations are displayed: EXP, IDA, IGI, IMP, IPI. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:68265

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	PDK2	IDA		Human	PMID:16401071
Molecular Function	GO:0005524	ATP binding	Pdk2	IDA		Rat	RGD:1582376|PMID:15312755
Molecular Function	GO:0005524	ATP binding	Pdk2	IMP		Rat	RGD:1582377|PMID:10698691
Molecular Function	GO:0005524	ATP binding	Pdk2	IDA		Rat	RGD:2307429|PMID:12573248
Molecular Function	GO:0005524	ATP binding	Pdk2	IDA		Rat	RGD:68199|PMID:9405293
Molecular Function	GO:0005515	protein binding	Pdk2	IPI	UniProtKB:O08908	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0032403	protein complex binding	Pdk2	IDA		Rat	RGD:2307429|PMID:12573248
Molecular Function	GO:0046982	protein heterodimerization activity	Pdk2	IDA		Rat	RGD:2307429|PMID:12573248
Molecular Function	GO:0042803	protein homodimerization activity	PDK2	IPI	UniProtKB:Q15119	Human	PMID:19833728
Molecular Function	GO:0042803	protein homodimerization activity	Pdk2	IDA		Rat	RGD:2307429|PMID:12573248
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pdk2	IDA		Rat	RGD:8553418|PMID:11486000
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK2	EXP		Human	PMID:11485553
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK2	IDA		Human	PMID:19833728
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	RGD:1582376|PMID:15312755
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IMP		Rat	RGD:1582377|PMID:10698691
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	RGD:2307429|PMID:12573248
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	RGD:68199|PMID:9405293
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	RGD:8553418|PMID:11486000
Cellular Component	GO:0005829	cytosol	PDK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	Pdk2	IDA		Mouse	MGI:MGI:4888421|PMID:21190881
Cellular Component	GO:0005739	mitochondrion	PDK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Pdk2	IDA		Mouse	MGI:MGI:3852644|PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pdk2	IDA		Mouse	MGI:MGI:2682130|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pdk2	IDA		Mouse	MGI:MGI:4888421|PMID:21190881
Cellular Component	GO:0005739	mitochondrion	Pdk2	IDA		Rat	RGD:1582377|PMID:10698691
Cellular Component	GO:0005654	nucleoplasm	PDK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Pdk2	IDA		Rat	RGD:2307429|PMID:12573248
Biological Process	GO:0031670	cellular response to nutrient	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0034614	cellular response to reactive oxygen species	PDK2	IMP		Human	PMID:21283817
Biological Process	GO:0042593	glucose homeostasis	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0008286	insulin receptor signaling pathway	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PDK2	IMP		Human	PMID:22123926
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Pdk2	IDA		Rat	RGD:8553418|PMID:11486000
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IDA		Rat	RGD:1582376|PMID:15312755
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IMP		Rat	RGD:1582377|PMID:10698691
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IDA		Rat	RGD:2307429|PMID:12573248
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IDA		Rat	RGD:68199|PMID:9405293
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0010565	regulation of cellular ketone metabolic process	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0006111	regulation of gluconeogenesis	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0010906	regulation of glucose metabolic process	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0006885	regulation of pH	Pdk2	IMP		Mouse	MGI:MGI:5428826|PMID:22360721

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction