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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
55492

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:55492

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Jan 27 18:25:03 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:55492
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:12970106
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:15625277
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:15831837
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:15862800
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:17609583
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:18703043
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:19307114
Molecular FunctionGO:0008144drug bindingHTR2BIDAHumanPMID:7926008
Molecular FunctionGO:0008144drug bindingHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Molecular FunctionGO:0001965G-protein alpha-subunit bindingHTR2BIMPHumanPMID:15625277
Molecular FunctionGO:0005515protein bindingHtr2bIPIUniProtKB:P25095RatPMID:19023134
Molecular FunctionGO:0005515protein bindingHtr2bIPIUniProtKB:P25095RatPMID:19023134
Molecular FunctionGO:0005099Ras GTPase activator activityHtr2bIMPMouseMGI:MGI:86840|PMID:8621713
Molecular FunctionGO:0051378serotonin bindingHTR2BIDAHumanPMID:15625277
Molecular FunctionGO:0051378serotonin bindingHTR2BIDAHumanPMID:15831837
Molecular FunctionGO:0051378serotonin bindingHTR2BIDAHumanPMID:15862800
Molecular FunctionGO:0051378serotonin bindingHTR2BIDAHumanPMID:17609583
Molecular FunctionGO:0051378serotonin bindingHTR2BIDAHumanPMID:19057895
Molecular FunctionGO:0051378serotonin bindingHTR2BIDAHumanPMID:7582481
Molecular FunctionGO:0051378serotonin bindingHTR2BIDAHumanPMID:7926008
Molecular FunctionGO:0051378serotonin bindingHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Molecular FunctionGO:0004993serotonin receptor activityHTR2BIDAHumanPMID:15862800
Molecular FunctionGO:0004993serotonin receptor activityHTR2BIDAHumanPMID:7582481
Molecular FunctionGO:0004993serotonin receptor activityHTR2BIDAHumanPMID:7926008
Molecular FunctionGO:0004993serotonin receptor activityHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Cellular ComponentGO:0005737cytoplasmHTR2BIDAHumanPMID:15925089
Cellular ComponentGO:0005737cytoplasmHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Cellular ComponentGO:0005622intracellularHtr2bIMPMouseMGI:MGI:86840|PMID:8621713
Cellular ComponentGO:0005886plasma membraneHTR2BIDAHumanPMID:12970106
Cellular ComponentGO:0005886plasma membraneHTR2BIDAHumanPMID:15625277
Cellular ComponentGO:0005886plasma membraneHTR2BIDAHumanPMID:15862800
Cellular ComponentGO:0005886plasma membraneHTR2BIDAHumanPMID:18703043
Cellular ComponentGO:0005886plasma membraneHTR2BIDAHumanPMID:19023134
Cellular ComponentGO:0005886plasma membraneHTR2BIDAHumanPMID:7926008
Cellular ComponentGO:0005886plasma membraneHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Cellular ComponentGO:0005886plasma membraneHtr2bIDARatPMID:19023134
Cellular ComponentGO:0005886plasma membraneHtr2bIDARatPMID:19023134
Biological ProcessGO:0007202activation of phospholipase C activityHTR2BIDAHumanPMID:16517693
Biological ProcessGO:0007202activation of phospholipase C activityHTR2BIDAHumanPMID:19057895
Biological ProcessGO:0019722calcium-mediated signalingHTR2BIMPHumanPMID:8882600
Biological ProcessGO:0003300cardiac muscle hypertrophyHtr2bIMPMouseMGI:MGI:4420536|PMID:19023134
Biological ProcessGO:0006874cellular calcium ion homeostasisHTR2BIDAHumanPMID:16517693
Biological ProcessGO:0006874cellular calcium ion homeostasisHTR2BIDAHumanPMID:19057895
Biological ProcessGO:0071502cellular response to temperature stimulusHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Biological ProcessGO:0006182cGMP biosynthetic processHTR2BIDAHumanPMID:12970106
Biological ProcessGO:0048598embryonic morphogenesisHtr2bIMPMouseMGI:MGI:707955|PMID:9165122
Biological ProcessGO:0070371ERK1 and ERK2 cascadeHTR2BIMPHumanPMID:19308295
Biological ProcessGO:0070371ERK1 and ERK2 cascadeHtr2bIMPMouseMGI:MGI:86840|PMID:8621713
Biological ProcessGO:0070371ERK1 and ERK2 cascadeHtr2bIMPMouseMGI:MGI:4457445|PMID:20450948
Biological ProcessGO:0002031G-protein coupled receptor internalizationHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayHTR2BIMPHumanPMID:15625277
Biological ProcessGO:0007507heart developmentHtr2bIMPMGI:MGI:1888735MouseMGI:MGI:1888653|PMID:10944220
Biological ProcessGO:0003007heart morphogenesisHtr2bIMPMouseMGI:MGI:707955|PMID:9165122
Biological ProcessGO:0014827intestine smooth muscle contractionHTR2BIMPHumanPMID:7599919
Biological ProcessGO:0014827intestine smooth muscle contractionHTR2BIMPHumanPMID:9186750
Biological ProcessGO:0043066negative regulation of apoptotic processHtr2bIMPMouseMGI:MGI:707955|PMID:9165122
Biological ProcessGO:0010507negative regulation of autophagyHTR2BIMPHumanPMID:20099302
Biological ProcessGO:0060548negative regulation of cell deathHTR2BIMPHumanPMID:20099302
Biological ProcessGO:0014033neural crest cell differentiationHtr2bIMPMouseMGI:MGI:707955|PMID:9165122
Biological ProcessGO:0001755neural crest cell migrationHtr2bIMPMouseMGI:MGI:707955|PMID:9165122
Biological ProcessGO:0014065phosphatidylinositol 3-kinase signalingHTR2BIDAHumanPMID:16517693
Biological ProcessGO:0016310phosphorylationHTR2BIMPHumanPMID:19308295
Biological ProcessGO:0051781positive regulation of cell divisionHtr2bIMPMouseMGI:MGI:86840|PMID:8621713
Biological ProcessGO:0008284positive regulation of cell proliferationHTR2BIDAHumanPMID:15625277
Biological ProcessGO:0008284positive regulation of cell proliferationHTR2BIMPHumanPMID:15925089
Biological ProcessGO:0001819positive regulation of cytokine productionHTR2BIDAHumanPMID:19023134
Biological ProcessGO:0050715positive regulation of cytokine secretionHtr2bIMPMouseMGI:MGI:4420536|PMID:19023134
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationHTR2BIMPHumanPMID:19308295
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationHtr2bIMPMouseMGI:MGI:4820706|PMID:19308295
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeHTR2BIDAHumanPMID:19057895
Biological ProcessGO:0043406positive regulation of MAP kinase activityHTR2BIDAHumanPMID:15625277
Biological ProcessGO:0051000positive regulation of nitric-oxide synthase activityHTR2BIDAHumanPMID:15625277
Biological ProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processHTR2BIDAHumanPMID:19057895
Biological ProcessGO:0032320positive regulation of Ras GTPase activityHtr2bIMPMouseMGI:MGI:86840|PMID:8621713
Biological ProcessGO:0070528protein kinase C signalingHTR2BIMPHumanPMID:20099302
Biological ProcessGO:0007205protein kinase C-activating G-protein coupled receptor signaling pathwayHtr2bIMPMouseMGI:MGI:4821070|PMID:17325130
Biological ProcessGO:0050795regulation of behaviorHTR2BIMPHumanPMID:21179162
Biological ProcessGO:0050795regulation of behaviorHtr2bIMPMouseMGI:MGI:4867565|PMID:21179162
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolHTR2BIDAHumanPMID:15862800
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolHTR2BIMPHumanPMID:18566482
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolHTR2BIMPHumanPMID:18703043
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolHTR2BIMPHumanPMID:8882600
Biological ProcessGO:0042493response to drugHTR2BIDAHumanPMID:15625277
Biological ProcessGO:0042493response to drugHTR2BIDAHumanPMID:15862800
Biological ProcessGO:0042493response to drugHTR2BIDAHumanPMID:18703043
Biological ProcessGO:0042493response to drugHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Biological ProcessGO:0007210serotonin receptor signaling pathwayHTR2BIMPHumanPMID:18703043
Biological ProcessGO:0007210serotonin receptor signaling pathwayHtr2bIDAMouseMGI:MGI:4821070|PMID:17325130
Biological ProcessGO:0042310vasoconstrictionHTR2BIMPHumanPMID:15625277

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory